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Although the oral route is the most convenient route for drug administration, there are a number of circumstances where this is not possible from either a clinical or pharmaceutical perspective. In these cases, the rectal route may represent a practical alternative and can be used to administer drugs for both local and systemic actions. The environment in the rectum is considered relatively constant and stable and has low enzymatic activity in comparison to other sections of the gastrointestinal tract. In addition, drugs can partially bypass the liver following systemic absorption, which reduces the hepatic first-pass effect. Therefore, rectal drug delivery can provide significant local and systemic levels for various drugs, despite the relatively small surface area of the rectal mucosa. Further development and optimization of rectal drug formulations have led to improvements in drug bioavailability, formulation retention, and drug release kinetics.
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Physiological and Pharmaceutical Considerations for Rectal Drug Formulations

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Physiological and Pharmaceutical Considerations for Rectal Drug Formulations

Die kommende Mutter meiner Babies, wunderschoene Titten und Riesenarsch und blaest und tittenfickt fuer eine ordentliche Samenladung. Lsd anal insertion with mouse. Therefore, the presence of G in our culture medium may be responsible for the induction of lamellar bodies, and perhaps phospholipidosis. Vladimirov for technical assistance, and Dr. The ratios of JC-1 red to green fluorescence intensity for different treatments were quantified Fig 2B. Tumour necrosis factor alpha suppression by MDMA is mediated by peripheral heteromeric nicotinic receptors. Histological scores of colon tissues.
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Lsd anal insertion with mouse

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